Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects.

@article{Herberg2014LowdoseBM,
  title={Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects.},
  author={S Herberg and Cristiano Susin and Manuel Pelaez and R. Nicole Howie and Rubens Moreno de Freitas and Jaebum Lee and James J Cray and Maribeth H. Johnson and Mohammed Elsalanty and Mark W Hamrick and Carlos M. Isales and Ulf M E Wikesj{\"o} and William D Hill},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 9-10},
  pages={
          1444-53
        }
}
Increasing evidence suggests that stromal cell-derived factor-1 (SDF-1/CXCL12) is involved in bone formation, though underlying molecular mechanisms remain to be fully elucidated. Also, contributions of SDF-1β, the second most abundant splice variant, as an osteogenic mediator remain obscure. We have shown that SDF-1β enhances osteogenesis by regulating bone morphogenetic protein-2 (BMP-2) signaling in vitro. Here we investigate the dose-dependent contribution of SDF-1β to suboptimal BMP-2… CONTINUE READING

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