Low-dose aspirin inhibits thromboxane, but not prostacyclin, production by human placental arteries.

@article{Thorp1988LowdoseAI,
  title={Low-dose aspirin inhibits thromboxane, but not prostacyclin, production by human placental arteries.},
  author={James A Thorp and Scott W. Walsh and P C Brath},
  journal={American journal of obstetrics and gynecology},
  year={1988},
  volume={159 6},
  pages={1381-4}
}
Preeclampsia is associated with increased thromboxane and decreased prostacyclin production by the placenta. Low-dose aspirin can selectively inhibit thromboxane production in the adult circulation, but its effects on placental vascular production of thromboxane and prostacyclin are incompletely understood. We therefore studied the effects of low-dose aspirin on the production rates of prostacyclin and thromboxane, with and without vasoconstricting doses of angiotensin II, in human placental… CONTINUE READING