Low-dose and high-dose aprotinin improve hemostasis in coronary operations.

  title={Low-dose and high-dose aprotinin improve hemostasis in coronary operations.},
  author={Ron G H Speekenbrink and C. R. H. Wildevuur and Augueste Sturk and L{\'e}on Eijsman},
  journal={The Journal of thoracic and cardiovascular surgery},
  volume={112 2},
Prophylactic aprotinin therapy has become a popular method to reduce bleeding associated with cardiac operations. Today essentially two dose regimens are used, a high-dose regimen with administration throughout the complete operative procedure and a low-dose regimen with administration only during bypass. In unblinded studies both regimens were found to be equally effective. This double-blind placebo-controlled study in 115 patients undergoing elective coronary artery bypass grafting was done… CONTINUE READING
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