Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis.

@article{Kelly1996LowdoseAI,
  title={Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis.},
  author={Brian John Peter. Kelly and S. K. Furney and Max Jessen and Ian M. Orme},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 12},
  pages={
          2809-12
        }
}
As a paradigm for chronic infectious diseases, tuberculosis exhibits a variety of clinical presentations, ranging from primary pulmonary tuberculosis to reactivation tuberculosis and cavitary disease. To date, the animal models used in evaluating chemotherapy of tuberculosis have been high-dose intravenous models that mimic the disseminated forms of the disease. In the present study, we have used a low-dose aerosol exposure model which we feel better reflects newly diagnosed tuberculosis in… CONTINUE READING
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