Low-dose acetylsalicylic acid use and the risk of upper gastrointestinal bleeding: a meta-analysis of randomized clinical trials and observational studies.

@article{Valkhoff2013LowdoseAA,
  title={Low-dose acetylsalicylic acid use and the risk of upper gastrointestinal bleeding: a meta-analysis of randomized clinical trials and observational studies.},
  author={Vera E. Valkhoff and Miriam C.J.M. Sturkenboom and Catherine Hill and Sander Veldhuyzen van Zanten and Ernst J Kuipers},
  journal={Canadian journal of gastroenterology = Journal canadien de gastroenterologie},
  year={2013},
  volume={27 3},
  pages={
          159-67
        }
}
BACKGROUND Low-dose acetylsalicylic acid (LDA, 75 mg/day to 325 mg/day) is recommended for primary and secondary prevention of cardiovascular events, but has been linked to an increased risk of upper gastrointestinal bleeding (UGIB). OBJECTIVE To analyze the magnitude of effect of LDA use on UGIB risk. METHODS The PubMed and Embase databases were searched for randomized controlled trials (RCTs) reporting UGIB rates in individuals receiving LDA, and observational studies of LDA use in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared.

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin

VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

European Stroke Prevention Study 2. Efficacy and safety data.

VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Adverse effects of low-dose aspirin in a healthy elderly population.

VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL