Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning.

@article{Teoh2003LowdoseTP,
  title={Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning.},
  author={Narci C-H Teoh and Isabelle Leclercq and Aileen Dela Pena and Geoffrey Farrell},
  journal={Hepatology},
  year={2003},
  volume={37 1},
  pages={118-28}
}
Tumor necrosis factor alpha (TNF-alpha) is implicated in the pathogenesis of hepatic ischemia reperfusion injury but can also prime hepatocytes to enter the cell cycle. Ischemic preconditioning protects against ischemia-reperfusion (IR) liver injury and is associated with activation of nuclear factor kappaB (NF-kappaB) and cell cycle entry. We examined the pattern of TNF-alpha release during hepatic IR in the presence or absence of ischemic preconditioning, and we tested whether a single low… CONTINUE READING

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