Low-dose Salmonella infection evades activation of flagellin-specific CD4 T cells.

@article{Srinivasan2004LowdoseSI,
  title={Low-dose Salmonella infection evades activation of flagellin-specific CD4 T cells.},
  author={Aparna Srinivasan and Joseph A. Foley and Rajesh Ravindran and Stephen J McSorley},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={
          4091-9
        }
}
Many pathogens can establish a lethal infection from relatively small inocula, yet the effect of infectious dose upon CD4 T cell activation is not clearly understood. This issue was examined by tracking Salmonella flagellin-specific SM1 T cells in vivo, after i.v. and oral challenge of mice with virulent Salmonella typhimurium. SM1 T cells rapidly expressed activation markers and expanded in response to high-dose infection but remained completely unresponsive in mice challenged with low doses… CONTINUE READING

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