Low-dose γ-rays modify CD4(+) T cell signalling response to simulated solar particle event protons in a mouse model.

@article{Rizvi2011LowdoseM,
  title={Low-dose γ-rays modify CD4(+) T cell signalling response to simulated solar particle event protons in a mouse model.},
  author={Asma Rizvi and Michael J Pecaut and James M. Slater and Shruti Subramaniam and Daila S. Gridley},
  journal={International journal of radiation biology},
  year={2011},
  volume={87 1},
  pages={
          24-35
        }
}
PURPOSE Astronauts on missions are exposed to low-dose/low-dose-rate (LDR) radiation and could receive high doses during solar particle events (SPE). This study investigated T cell function in response to LDR radiation and simulated SPE (sSPE) protons, alone and in combination. MATERIALS AND METHODS C57BL/6 mice received LDR γ-radiation (⁵⁷Co) to a total dose of 0.01 Gray (Gy) at 0.179 mGy/h, either with or without subsequent exposure to 1.7 Gy sSPE protons delivered over 36 h. Mice were… CONTINUE READING
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