Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure.

@article{Hanaya2012LowDO,
  title={Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure.},
  author={Ryosuke Hanaya and Hisato Hosoyama and Sei Sugata and Mai Tokudome and Hitoshi Hirano and Hiroshi Tokimura and Kaoru Kurisu and Tadao Serikawa and Masashi Sasa and Kazunori Arita},
  journal={Neuroscience},
  year={2012},
  volume={221},
  pages={12-20}
}
The spontaneously epileptic rat (SER) is a double mutant (zi/zi, tm/tm) which begins to exhibit tonic convulsions and absence seizures after 6 weeks of age, and repetitive tonic seizures over time induce sclerosis-like changes in SER hippocampus with high brain-derived neurotrophic factor (BDNF) expression. Levetiracetam, which binds to synaptic vesicle protein 2A (SV2A), inhibited both tonic convulsions and absence seizures in SERs. We studied SER brains histologically and… CONTINUE READING

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