Low-density neuronal networks cultured using patterned poly-l-lysine on microelectrode arrays

@article{Jun2007LowdensityNN,
  title={Low-density neuronal networks cultured using patterned poly-l-lysine on microelectrode arrays},
  author={S. Jun and M. Hynd and N. Dowell-Mesfin and Karen L. Smith and J. Turner and W. Shain and S. Kim},
  journal={Journal of Neuroscience Methods},
  year={2007},
  volume={160},
  pages={317-326}
}
  • S. Jun, M. Hynd, +4 authors S. Kim
  • Published 2007
  • Biology, Medicine
  • Journal of Neuroscience Methods
Synaptic activity recorded from low-density networks of cultured rat hippocampal neurons was monitored using microelectrode arrays (MEAs). Neuronal networks were patterned with poly-l-lysine (PLL) using microcontact printing (microCP). Polydimethysiloxane (PDMS) stamps were fabricated with relief structures resulting in patterns of 2 microm-wide lines for directing process growth and 20 microm-diameter circles for cell soma attachment. These circles were aligned to electrode sites. Different… Expand
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