Low-density lipoproteins induce heat shock protein 27 dephosphorylation, oligomerization, and subcellular relocalization in human vascular smooth muscle cells.

@article{GarcaArguinzonis2010LowdensityLI,
  title={Low-density lipoproteins induce heat shock protein 27 dephosphorylation, oligomerization, and subcellular relocalization in human vascular smooth muscle cells.},
  author={Ma{\'i}sa Garc{\'i}a-Arguinzonis and Teresa Padro and Roberta Lugano and Vicenta Llorente-Cort{\'e}s and L Badimon},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 6},
  pages={
          1212-9
        }
}
OBJECTIVE High levels of circulating low-density lipoproteins (LDL) are a major atherosclerotic risk factor. The effects of intimal LDL on vascular smooth muscle cell (VSMC) phenotype and function during plaque remodeling and vascular repair are not fully understood. We have investigated whether exposure of VSMC to LDL induces changes on the proteomic profile of the heat shock protein (HSP) family-molecular chaperones involved in atherosclerosis. Methods & Results- 2D electrophoresis… CONTINUE READING

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