Corpus ID: 35731668

Low-density lipoprotein stimulation of mesangial cell fibronectin synthesis: role of protein kinase C and transforming growth factor-beta.

@article{Studer1995LowdensityLS,
  title={Low-density lipoprotein stimulation of mesangial cell fibronectin synthesis: role of protein kinase C and transforming growth factor-beta.},
  author={Rebecca K. Studer and Patricia A. Craven and Frederick R. DeRubertis},
  journal={The Journal of laboratory and clinical medicine},
  year={1995},
  volume={125 1},
  pages={
          86-95
        }
}
  • Rebecca K. Studer, Patricia A. Craven, Frederick R. DeRubertis
  • Published in
    The Journal of laboratory and…
    1995
  • Chemistry, Medicine
  • Low-density lipoprotein (LDL) cholesterol has been implicated in the pathogenesis of glomerulosclerosis in diabetes and other forms of glomerular injury. In the present study we evaluated the effect of LDL on fibronectin synthesis in cultured rat mesangial cells (MCs) and the roles of protein kinase C (PKC) and transforming growth factor-beta (TGF-beta) in mediating this LDL action. In MCs, 25 micrograms to 100 micrograms/ml LDL increased PKC activity within 15 minutes, as reflected by enhanced… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-9 OF 9 CITATIONS

    LDL stimulates collagen mRNA synthesis in mesangial cells through induction of PKC and TGF-β expression.

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C.

    VIEW 3 EXCERPTS
    CITES BACKGROUND