Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase.

@article{Pocivavsek2009LowdensityLR,
  title={Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase.},
  author={Ana Pocivavsek and Mark P Burns and G. William Rebeck},
  journal={Glia},
  year={2009},
  volume={57 4},
  pages={444-53}
}
Apolipoprotein E (apoE) has been implicated in modulating the central nervous system (CNS) inflammatory response. However, the molecular mechanisms involved in apoE-dependent immunomodulation are poorly understood. We hypothesize that apoE alters the CNS inflammatory response by signaling via low-density lipoprotein (LDL) receptors in glia. To address this hypothesis, we used a small bioactive peptide formed from the receptor-binding domain of apoE, apoE peptide (EP), to study LDL receptor… CONTINUE READING

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