Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.

@article{Basak2012LowdensityLR,
  title={Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.},
  author={Jacob Martin Basak and Philip Benjamin Verghese and Hyejin Yoon and Jungsu Kim and David M Holtzman},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 17},
  pages={
          13959-71
        }
}
Accumulation of the amyloid β (Aβ) peptide within the brain is hypothesized to be one of the main causes underlying the pathogenic events that occur in Alzheimer disease (AD). Consequently, identifying pathways by which Aβ is cleared from the brain is crucial for better understanding of the disease pathogenesis and developing novel therapeutics. Cellular uptake and degradation by glial cells is one means by which Aβ may be cleared from the brain. In the current study, we demonstrate that… CONTINUE READING

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