Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

@article{Kowal1989LowDL,
  title={Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.},
  author={Robert C. Kowal and Joachim Herz and Joseph L Goldstein and V. Esser and Michael Scott Brown},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 15},
  pages={5810-4}
}
Low density lipoprotein receptor-related protein (LRP) is a recently described cell-surface protein of 4544 amino acids that contains reiterated sequences found in the 839-amino acid receptor for low density lipoprotein (LDL). In the current studies, we purified LRP from rat liver, prepared polyclonal antibodies that recognize the extracellular domain, and demonstrated an immunoreactive protein of approximately 600 kDa in human fibroblasts. The function of this LRP was studied in mutant human… CONTINUE READING

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