Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.

@article{Emonard2004LowDL,
  title={Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.},
  author={Herv{\'e} Emonard and Georges Bellon and Linda Troeberg and Alix Berton and Arnaud Robinet and Patrick Henriet and Etienne Marbaix and Kirstine Kirkegaard and L{\'a}szl{\'o} Patthy and Yves Eeckhout and Hideaki Nagase and William G Hornebeck and Pierre J. Courtoy},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 52},
  pages={54944-51}
}
The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance of various proteinases and proteinase.inhibitor complexes, including thrombospondin (TSP)-dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector of extracellular matrix remodeling and cancer progression. However, the zymogen of MMP-2 (pro-MMP-2) mostly occurs in tissues as a complex with the tissue inhibitor of MMPs (TIMP-2). Here we show that clearance of the pro-MMP… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

The role of thrombospondins in wound healing, ischemia, and the foreign body reaction

Journal of Cell Communication and Signaling • 2009
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…