Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.

@article{Wicher2005LowdensityLR,
  title={Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.},
  author={Grzegorz Wicher and M{\aa}rten Larsson and Lars Rask and H{\aa}kan Aldskogius},
  journal={The Journal of comparative neurology},
  year={2005},
  volume={492 2},
  pages={123-31}
}
The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands. Megalin is expressed in the neuroepithelium during central nervous system (CNS) development. Mice with homozygous deletions of the megalin gene show severe forebrain abnormalities. The possible role of megalin in the developing spinal cord, however, is unknown. Here we examined the spatial and temporal expression pattern of megalin in the embryonic… CONTINUE READING

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