Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice

@article{Wang2017LowdensityLR,
  title={Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice},
  author={Gaiqing Wang and A. Manaenko and Anwen Shao and Yibo Ou and P. Yang and Enkhjargal Budbazar and Derek Nowrangi and J. Zhang and J. Tang},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={2017},
  volume={37},
  pages={1299 - 1310}
}
  • Gaiqing Wang, A. Manaenko, +6 authors J. Tang
  • Published 2017
  • Medicine, Biology
  • Journal of Cerebral Blood Flow & Metabolism
  • Heme-degradation after erythrocyte lysis plays an important role in the pathophysiology of intracerebral hemorrhage. Low-density lipoprotein receptor-related protein-1 is a receptor expressed predominately at the neurovascular interface, which facilitates the clearance of the hemopexin and heme complex. In the present study, we investigated the role of low-density lipoprotein receptor-related protein-1 in heme removal and neuroprotection in a mouse model of intracerebral hemorrhage. Endogenous… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 50 REFERENCES
    Iron and Iron-Handling Proteins in the Brain After Intracerebral Hemorrhage
    307
    Identification of the receptor scavenging hemopexin-heme complexes.
    345
    Heme and Iron Metabolism: Role in Cerebral Hemorrhage
    343
    Brain edema after intracerebral hemorrhage in rats: the role of iron overload and aquaporin 4.
    63
    Hemoglobin and heme scavenger receptors.
    130