Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice.

@article{Wang2017LowdensityLR,
  title={Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice.},
  author={Gaiqing Wang and Anatol Manaenko and Anwen Shao and Yibo Ou and Peng Yang and Enkhjargal Budbazar and Derek S Nowrangi and John H Zhang and Jiping Tang},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2017},
  volume={37 4},
  pages={1299-1310}
}
Heme-degradation after erythrocyte lysis plays an important role in the pathophysiology of intracerebral hemorrhage. Low-density lipoprotein receptor-related protein-1 is a receptor expressed predominately at the neurovascular interface, which facilitates the clearance of the hemopexin and heme complex. In the present study, we investigated the role of low-density lipoprotein receptor-related protein-1 in heme removal and neuroprotection in a mouse model of intracerebral hemorrhage. Endogenous… CONTINUE READING
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