Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.

@article{Song2009LowdensityLR,
  title={Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.},
  author={Heesang Song and Yonghe Li and Jiyeon Lee and Alan L. Schwartz and Guojun D Bu},
  journal={Cancer research},
  year={2009},
  volume={69 3},
  pages={
          879-86
        }
}
The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor involved in the metabolism of various extracellular ligands, including proteinases, that play critical roles in tumor invasion. Although several studies have shown an increased expression of LRP1 in cancer cells, its function in tumor development and progression remains largely unclear. Here, we reveal a novel mechanism by which LRP1 induces the expression of matrix metalloproteinase 2 (MMP2… CONTINUE READING

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Expression of LRP1 Promotes U87 Invasion by Up-regulating MMP9 www.aacrjournals.org

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