Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration.

@article{Rabiej2016LowDL,
  title={Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration.},
  author={Verena K Rabiej and Thorsten Pflanzner and Timo Wagner and Kristina Goetze and Steffen E. Storck and Johannes A Eble and Sascha Weggen and Wolfgang F Mueller-Klieser and Claus U. Pietrzik},
  journal={Experimental cell research},
  year={2016},
  volume={340 1},
  pages={102-15}
}
The low density lipoprotein receptor-related protein 1 (LRP1) has been shown to interact with β1-integrin and regulate its surface expression. LRP1 knock-out cells exhibit altered cytoskeleton organization and decreased cell migration. Here we demonstrate coupled endocytosis of LRP1 and β1-integrin and the involvement of the intracellular NPxY2 motif of LRP1 in this process. Mouse embryonic fibroblasts harboring a knock in replacement of the NPxY2 motif of LRP1 by a multiple alanine cassette… CONTINUE READING
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