Low-density lipoprotein oxidation, antioxidants, and atherosclerosis: a clinical biochemistry perspective.

@article{Jialal1996LowdensityLO,
  title={Low-density lipoprotein oxidation, antioxidants, and atherosclerosis: a clinical biochemistry perspective.},
  author={Ishwarlal Jialal and Sridevi Devaraj},
  journal={Clinical chemistry},
  year={1996},
  volume={42 4},
  pages={
          498-506
        }
}
Cardiovascular disease is the leading cause of mortality in westernized populations. An increased concentration of plasma low-density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerosis. Several lines of evidence support a role for oxidatively modified LDL in atherosclerosis and for its in vivo existence. Antioxidants have been shown to decrease atherosclerotic lesion formation in animal models and decrease LDL oxidation; the evaluation of LDL oxidation in vivo is… CONTINUE READING

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