Low-density lipoprotein cholesterol levels are associated with insulin-like growth factor-1 in short-stature children and adolescents: a cross-sectional study

  title={Low-density lipoprotein cholesterol levels are associated with insulin-like growth factor-1 in short-stature children and adolescents: a cross-sectional study},
  author={Qianqian Zhao and Yingzhe Jiang and Mei Zhang and Yuntian Chu and Baolan Ji and H. Pan and B. Ban},
  journal={Lipids in Health and Disease},
BackgroundElevated low-density lipoprotein cholesterol (LDL-C) levels in childhood have recently been found to be the strongest predictive risk factor for coronary artery disease in adulthood. There is an increased level of LDL-C in children and adolescents with short stature. However, the underlying factors associated with increased LDL-C levels in children and adolescents with short stature are unknown. In addition, the insulin-like growth factor 1 (IGF-1) level in the short-stature… Expand
3 Citations
Relationship between hemoglobin and insulin-like growth factor-1 in children and adolescents with idiopathic short stature
It is demonstrated that Hb is associated with IGF-1 in Chinese children and adolescents with ISS, but when the concentration of Hb exceeded a certain range, with the increase of HB, IGF- 1 decreased instead. Expand
Association between serum uric acid and triglycerides in Chinese children and adolescents with short stature
The present study identified the non-linear association of SUA and TG levels with short children and adolescents, based on BMI status, and suggests that health status should be considered for short stature children with high SUA levels, especially in children with a high BMI standard deviation score. Expand
Cholesterol Derivatives as Promising Anticancer Agents in Glioblastoma Metabolic Therapy
The potential of targeting cholesterol metabolism using cholesterol derivatives as a pharmacological alternative to current therapeutic strategy for glioblastoma is discussed. Expand


Usefulness of childhood low-density lipoprotein cholesterol level in predicting adult dyslipidemia and other cardiovascular risks. The Bogalusa Heart Study.
Adulthood dyslipidemia, as defined by the National Cholesterol Education Program criterion, was best predicted by childhood LDL-C level among other lipoprotein variables, which is helpful in targeting individuals at risk early in life. Expand
LDL cholesterol level in fifth-grade schoolchildren associates with stature
The relationship of stature to LDL levels in children in the West Virginia Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project was investigated to determine whether the genetically determined inverse relationship observed in adults would be evident in fifth graders. Expand
Utility of Currently Recommended Pediatric Dyslipidemia Classifications in Predicting Dyslipidemia in Adulthood: Evidence From the Childhood Determinants of Adult Health (CDAH) Study, Cardiovascular Risk in Young Finns Study, and Bogalusa Heart Study
The separate use of NHANES cut points for high-density lipoprotein cholesterol and NCEP cut points from National Health and Nutrition Examination Survey yielded the most accurate classification of adolescents who developed dyslipidemia in adulthood. Expand
Effects of Growth Hormone Treatment on Lipid Profiles
GH treatment is clearly a pharmacological therapy in SGA short children and so may also be in GHD short children at the Japanese standard therapeutic dose and its effect has the possibility of medical properties. Expand
Utility of Childhood Non–High-Density Lipoprotein Cholesterol Levels in Predicting Adult Dyslipidemia and Other Cardiovascular Risks: The Bogalusa Heart Study
Adverse levels of non–high-density lipoprotein cholesterol versus low-density cholesterol in childhood not only equally persist over time and better predict adult dyslipidemia but also are related to nonlipid cardiovascular risk factors in adulthood. Expand
Relationship between insulin-like growth factor-I and low-density lipoprotein cholesterol levels in primary hypothyroidism in women.
The data suggest that in hypothyroidism, IGF-I is a determinant of the concentration of LDL cholesterol and plasma lipoprotein metabolism by lowering the activity of the salt-resistant lipase (liver lipase). Expand
LDL-cholesterol and body mass index among Japanese schoolchildren: a population-based cross-sectional study
A statistically significant association between LDL-C levels and BMI was observed in Japanese school children and a higher BMI category was associated with a higher prevalence of HLDL-C regardless of sex or grade level. Expand
Associations between body height, body composition and cholesterol levels in middle-aged men. The coronary risk factor study in southern Sweden (CRISS)
Body height had an independent and inverse relation to serum cholesterol and non-HDL cholesterol in middle-aged men, and the lipid pattern suggests that the underlying mechanism might be different from the traditional association between lipids and the metabolic syndrome. Expand
Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents
Prevalence of dyslipidemia is high in obese children, and hypertriglyceridemicemia is in the foreground. Expand
Insulin-like growth factor I and low-density-lipoprotein cholesterol in women during high- and low-fat feeding.
IGF-I may contribute to the regulation of LDL cholesterol in mildly hypercholesterolemic women but may not mediate the beneficial response to reduced fat intake. Expand