Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism.

@article{Block1988LowDL,
  title={Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism.},
  author={Lutz H. Block and Marcelo Knorr and Esther Vogt and Rudolf A. Locher and Wilhelm Vetter and Peter Groscurth and B Y Qiao and Daniel Pometta and Robert D. James and Martin Regenass},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 3},
  pages={885-9}
}
Low density lipoprotein (LDL), at concentrations high enough for receptor binding but not high enough to saturate the receptor, induces activation of phosphatidylinositol (PtdIns) turnover in a variety of cell types with various biological functions. Using both biochemical and electron microscopic studies, we have shown that blood platelets take up and degrade LDL in a manner reminiscent of phagocytic cell types. The activation of both PtdIns turnover and LDL metabolism is inhibited by high… CONTINUE READING