Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.

@article{Li2002LowDL,
  title={Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.},
  author={Yonghe Li and Jane M Knisely and Wenyan Lu and Lynn M. McCormick and Jieyi Wang and Jack Henkin and Alan L. Schwartz and Guojun Bu},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 44},
  pages={42366-71}
}
The low density lipoprotein (LDL) receptor-related protein 1B (LRP1B) is a newly identified member of the LDL receptor family and is closely related to LRP. It was discovered as a putative tumor suppressor and is frequently inactivated in lung cancer cells. In the present study, we used an LRP1B minireceptor (mLRP1B4), which mimics the function and trafficking of LRP1B, to explore the roles of LRP1B on the plasminogen activation system. We found that mLRP1B4 and urokinase plasminogen activator… CONTINUE READING
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