Low-density DNA microarrays are versatile tools to screen for known mutations in hypertrophic cardiomyopathy.

@article{Waldmller2002LowdensityDM,
  title={Low-density DNA microarrays are versatile tools to screen for known mutations in hypertrophic cardiomyopathy.},
  author={Stephan Waldm{\"u}ller and Petra Freund and Simon Mauch and Roland Toder and H. R. Vosberg},
  journal={Human mutation},
  year={2002},
  volume={19 5},
  pages={
          560-9
        }
}
Familial hypertrophic cardiomyopathy (HCM or CMH) is a myocardial disorder caused by mutations that affect the contractile machinery of heart muscle cells. Genetic testing of HCM patients is hampered by the fact that mutations in at least eight different genes contribute to the disease. An affordable high-throughput mutation detection method is as yet not available. Since a significant number of mutations have been repeatedly found in unrelated families, we consider it feasible to pre-screen… CONTINUE READING
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