Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept.

@article{Hrabovszky2012LowDO,
  title={Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept.},
  author={Erik Hrabovszky and M{\'a}t{\'e} T. Sipos and Csilla S. Moln{\'a}r and Philippe Ciofi and Be{\'a}ta {\'A}. Borsay and P{\'e}ter Gergely and L{\'a}szl{\'o} Herczeg and Stephen R. Bloom and Mohammad A. Ghatei and Waljit S. Dhillo and Zsolt Liposits},
  journal={Endocrinology},
  year={2012},
  volume={153 10},
  pages={4978-89}
}
Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis for the KP/NKB/DYN (KNDy) neuron concept; in both sexes, KNDy neuropeptides have been implicated in the generation of GnRH neurosecretory pulses and in the negative feedback effects of sexual steroids to the reproductive axis. To test the… CONTINUE READING

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