Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models.

@article{Nassimi2009LowCO,
  title={Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models.},
  author={Matthias Nassimi and Carsten Schleh and Hans-Dieter Lauenstein and Riem Hussein and Katrin L{\"u}bbers and Gerhard Pohlmann and Simone Switalla and Katherina Sewald and Meike Mueller and Norbert Krug and Christel Charlotte M{\"u}ller-Goymann and Armin Braun},
  journal={Inhalation toxicology},
  year={2009},
  volume={21 Suppl 1},
  pages={104-9}
}
The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) for human lung as a suitable drug delivery system (DDS). Therefore we used a human alveolar epithelial cell line (A549) and murine precision-cut lung slices (PCLS) to estimate the tolerable doses of these particles for lung cells. A549 cells (in vitro) and precision-cut lung slices (ex vivo) were incubated with SLN20 (20% phospholipids in the lipid matrix of the particles) and SLN50 (50… CONTINUE READING
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