Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma.

@article{Preter2008LowcostDM,
  title={Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma.},
  author={Katleen De Preter and Bj{\"o}rn Menten and Sara De Brouwer and Candy Kumps and Evi Michels and Nadine Van Roy and Jo Vandesompele and Frank Speleman},
  journal={Cancer letters},
  year={2008},
  volume={269 1},
  pages={111-6}
}
ArrayCGH is commonly used for high-resolution detection of copy-number alterations in tumours, allowing identification of chromosomal aberrations with prognostic or diagnostic relevance. Currently available arrayCGH platforms are still very expensive for analysis of large sets of samples. For this purpose, we have constructed a dedicated mini-array that is enriched for BAC/PAC clones in the prognostic important regions for neuroblastoma and that only covers a small area on the slide, allowing… CONTINUE READING