Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.

@article{Head1997LowCO,
  title={Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.},
  author={Charlene Head and Carlo Brugnara and Ricardo Martinez-Ruiz and Robert Michael Kacmarek and K. R. Bridges and David P. Kuter and Kenneth D. Bloch and Warren M. Concord Zapol},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 5},
  pages={
          1193-8
        }
}
The hallmark of sickle cell disease (SCD) is the polymerization of deoxygenated sickle hemoglobin (HbS). In SCD patients, one strategy to reduce red blood cell (RBC) sickling is to increase HbS oxygen affinity. Our objective was to determine if low concentrations of nitric oxide (NO) gas would augment the oxygen affinity of RBCs containing homozygous HbS (SS). Blood containing normal adult hemoglobin (AA) or SS RBCs was incubated in vitro in the presence of varying concentrations of NO up to 80… CONTINUE READING

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