Low concentrations of an nitric oxide-donor combined with a liposoluble antioxidant compound enhance protection against reperfusion injury in isolated rat hearts.

@article{Rastaldo2010LowCO,
  title={Low concentrations of an nitric oxide-donor combined with a liposoluble antioxidant compound enhance protection against reperfusion injury in isolated rat hearts.},
  author={Raffaella Rastaldo and Sandra Cappello and A Folino and Antonella Di Stilo and Konstantin Chegaev and Isabella Tritto and Pasquale Pagliaro and Gianni A Losano},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2010},
  volume={61 1},
  pages={21-7}
}
Nitric oxide (NO) and reactive oxygen species (ROS) are double-edged swords in reperfused hearts. The effects of a NO-donor and an antioxidant compound against ischemia/reperfusion were studied. The compounds were tested separately, as a mixture and as a new hybrid molecule containing both leads. Isolated rat hearts underwent 30 min global ischemia and 2 hrs reperfusion. Compounds were infused either at 1 or 10 microM concentrations during the first 20 min of reperfusion. Hybrid was also tested… CONTINUE READING

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