Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus.

@article{Li2015LowCO,
  title={Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus.},
  author={Yuanyuan Li and Wei Xu and Xiao-Ran Chen and Qin-Qin Lou and Wu-ji Wei and Zhanfen Qin},
  journal={Aquatic toxicology},
  year={2015},
  volume={158},
  pages={230-7}
}
Trenbolone, as a growth promoter in animal agriculture, has become an environmental androgen in surface water. Here, we aimed to reveal the effects of 17β-trenbolone on survival, growth, and gonadal differentiation in the frog Pelophylax nigromaculatus, which is widespread in East Asia and undergoing population decline. P. nigromaculatus tadpoles were exposed to 17β-trenbolone (0.1, 1, 10 μg/L) from Gosner stage 24/25 to complete metamorphosis. We found that 17β-trenbolone resulted in… CONTINUE READING
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