Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.

@article{Qin2008LowCO,
  title={Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.},
  author={Xu-Jun Qin and Laurie G. Hudson and Wenlan Liu and Graham S. Timmins and Ke Jian Liu},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={232 1},
  pages={41-50}
}
Epidemiological studies have associated arsenic exposure with many types of human cancers. Arsenic has also been shown to act as a co-carcinogen even at low concentrations. However, the precise mechanism of its co-carcinogenic action is unknown. Recent studies indicate that arsenic can interfere with DNA-repair processes. Poly(ADP-ribose) polymerase (PARP)-1 is a zinc-finger DNA-repair protein, which can promptly sense DNA strand breaks and initiate DNA-repair pathways. In the present study, we… CONTINUE READING