Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum.

@article{McGlynn2013LowCF,
  title={Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum.},
  author={Angela P. McGlynn and Gillian Wasson and Sharleen L O'Reilly and Helene McNulty and C. Stephen Downes and Chin-Kuo Chang and Leane Hoey and Anne M. Molloy and Mary Ward and J. J. Strain and George McKerr and Donald George Weir and John M. Scott},
  journal={The Journal of nutrition},
  year={2013},
  volume={143 1},
  pages={27-33}
}
Low folate status is a risk factor for colon carcinogenesis; mechanisms proposed to account for this relationship include uracil misincorporation into DNA and global DNA hypomethylation. We investigated whether such biomarkers are related to folate status in isolated colonocytes from colonoscopy patients. In cases with adenomatous polyps (n = 40) or hyperplastic polyps (n = 16), colonocytes were isolated from biopsies from the polyp, from a site adjacent to the polyp, and from normal mucosa 10… CONTINUE READING
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