Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease.

@article{Charlton2008LowCL,
  title={Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease.},
  author={Michael R. Charlton and Paul Angulo and Naga Chalasani and Ralph Merriman and K. Viker and Phunchai Charatcharoenwitthaya and Schuyler Sanderson and Samer Gawrieh and Anuradha Krishnan and Keith M Lindor},
  journal={Hepatology},
  year={2008},
  volume={47 2},
  pages={484-92}
}
UNLABELLED The biological basis of variability in histological progression of nonalcoholic fatty liver disease (NAFLD) is unknown. Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone and has been shown to influence sensitivity to oxidative stress, insulin sensitivity, and expression of peroxisome proliferator-activated receptor alpha and procollagen messenger RNA. Our aim was to determine whether more histologically advanced NAFLD is associated with low circulating levels of DHEA… CONTINUE READING
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