Low cerebrospinal-fluid concentrations of soluble amyloid beta-protein precursor in hereditary Alzheimer's disease.

@article{Farlow1992LowCC,
  title={Low cerebrospinal-fluid concentrations of soluble amyloid beta-protein precursor in hereditary Alzheimer's disease.},
  author={M R Farlow and Bernardino Ghetti and Merrill D L Benson and Jeffrey S. Farrow and William E. Van Nostrand and Steven L. Wagner},
  journal={Lancet},
  year={1992},
  volume={340 8817},
  pages={453-4}
}
In Alzheimer's disease, deposits of amyloid beta-protein are apparently derived from intracellular processing of a large precursor protein. We have measured concentrations of this precursor in cerebrospinal fluid (CSF) from six members of a family affected by presenile Alzheimer's disease associated with a point mutation of the precursor gene. One gene carrier with clinical signs of the disorder had low CSF concentrations of the precursor, similar to those of three patients with sporadic… CONTINUE READING

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