Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress.

@article{Higashi2003LowBM,
  title={Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress.},
  author={Yukihito Higashi and Shota Sasaki and Keigo Nakagawa and Masashi Kimura and Kensuke Noma and Satoshi Sasaki and Keiko Hara and Hideo Matsuura and Chikara Goto and Tetsuya Oshima and Kazuaki Chayama and Masao Yoshizumi},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={42 2},
  pages={256-63}
}
OBJECTIVES The purpose of this study was to evaluate the relationship between body mass index (BMI), including low BMIs, and endothelial function. BACKGROUND Epidemiologic study has demonstrated that not only obesity but also a low BMI may be a risk factor for cardiovascular disease. METHODS The forearm blood flow (FBF) response to acetylcholine (ACh) and isosorbide dinitrate (ISDN) was measured in 87 healthy young men (15 low BMI, 51 normal, 14 obese, and 7 extremely obese). RESULTS… CONTINUE READING

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