Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.

@article{Wu1998LowBB,
  title={Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.},
  author={Dafang Wu and John G. Clement and William M Pardridge},
  journal={Brain research},
  year={1998},
  volume={791 1-2},
  pages={313-6}
}
The blood-brain barrier (BBB) permeability to [3H]-azidodeoxythymidine (AZT), deoxythiacytidine (3TC), and thymidine was studied using both an intravenous injection/external organ (IV/EO) method and an internal carotid artery perfusion (ICAP) technique in parallel with [14C]-sucrose as a plasma volume marker. The brain volumes of distribution (VD) of the three compounds approximated that of sucrose with either method. Although the lipid solubility of AZT, as determined by the 1-octanol/buffer… CONTINUE READING

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