Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method.

@article{GarcaCobos2008LowBA,
  title={Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method.},
  author={Silvia Garc{\'i}a-Cobos and Jos{\'e} Guevara Campos and Federico Rom{\'a}n and Cristina Carrera and Mar{\'i}a Teresa P{\'e}rez-V{\'a}zquez and Bel{\'e}n Aracil and Jes{\'u}s Oteo},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 7},
  pages={2407-14}
}
Ampicillin resistance in Haemophilus influenzae due to alterations in penicillin-binding proteins (beta-lactamase negative ampicillin resistant [BLNAR]) is acquiring increasing clinical and epidemiological importance. BLNAR strains with low ampicillin MICs (0.5 to 4 microg/ml) represent the majority of this population in Europe and the United States, but separating them from susceptible isolates is challenging. To investigate the best method to identify low-BLNAR strains, we studied the… CONTINUE READING

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