Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay.

@article{Iranmanesh1994LowBA,
  title={Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay.},
  author={Ali Iranmanesh and B Grisso and Johannes D. Veldhuis},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={78 3},
  pages={
          526-35
        }
}
Serum GH concentrations assessed by conventional RIA and immunoradiometric assay (IRMA) are often undetectable in healthy fed and awake humans. Serum GH concentrations are also low in obese, hypothyroid, middle-aged, and older individuals. Accordingly, to better investigate the pathophysiology of GH release in relatively hyposomatotropic states, we compared a new and putatively ultrasensitive GH chemiluminescence (CL) assay with a conventional IRMA. We report that the sensitivity of the CL… CONTINUE READING

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