Low- and high-grade bladder cancer determination via human serum-based metabolomics approach.

@article{Bansal2013LowAH,
  title={Low- and high-grade bladder cancer determination via human serum-based metabolomics approach.},
  author={Navneeta Bansal and Ashish Gupta and Nilay Mitash and Prashant Singh Shakya and Anil Mandhani and Abbas Ali Mahdi and Satya Narain Sankhwar and Sudhir Kumar Mandal},
  journal={Journal of proteome research},
  year={2013},
  volume={12 12},
  pages={
          5839-50
        }
}
To address the shortcomings of urine cytology and cystoscopy for probing and grading urinary bladder cancer (BC), we applied (1)H nuclear magnetic resonance (NMR) spectroscopy as a surrogate method for the identification of BC. This study includes 99 serum samples comprising low-grade (LG; n = 36) and high-grade (HG; n = 31) BC as well as healthy controls (HC; n = 32). (1)H NMR-derived serum data were analyzed using orthogonal partial least-squares discriminant analysis (OPLS-DA). OPLS-DA… CONTINUE READING

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