Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2.

@article{Ning2010LowAH,
  title={Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2.},
  author={Jiao-lin Ning and Li-wen Mo and Xi-nan Lai},
  journal={Chinese medical journal},
  year={2010},
  volume={123 8},
  pages={1063-9}
}
BACKGROUND Reactive oxygen species (ROS) may play both physiological and pathophysiological roles. Transcription factor NF-E2-related factor 2 (Nrf2) regulates antioxidant response element (ARE)-mediated genes expression and coordinates induction of chemoprotective proteins in response to physical and chemical stresses. The exact role of Nrf2 in cellular responses to different levels of oxidative stresses remains unknown. METHODS Rat pulmonary microvascular endothelial cells were cultured and… CONTINUE READING

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