Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses

@article{Mamluk2017LowAC,
  title={Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses},
  author={L. Mamluk and H. Edwards and J. Savovi{\'c} and V. Leach and T. Jones and T. Moore and S. Ijaz and S. Lewis and J. Donovan and D. Lawlor and George Davey Smith and A. Fraser and L. Zuccolo},
  journal={BMJ Open},
  year={2017},
  volume={7}
}
Objectives To determine the effects of low-to-moderate levels of maternal alcohol consumption in pregnancy on pregnancy and longer-term offspring outcomes. Search strategy Medline, Embase, Web of Science and Psychinfo from inception to 11 July 2016. Selection criteria Prospective observational studies, negative control and quasiexperimental studies of pregnant women estimating effects of light drinking in pregnancy (≤32 g/week) versus abstaining. Pregnancy outcomes such as birth weight and… Expand
The Effectiveness of Smoking Cessation, Alcohol Reduction, Diet and Physical Activity Interventions in Improving Maternal and Infant Health Outcomes: A Systematic Review of Meta-Analyses
TLDR
A synthesis of evidence from meta-analyses on the effectiveness of interventions at reducing risk of adverse health outcomes in pregnancy is reported, with consistent evidence from diet and physical activity interventions for a significantly reduced mean gestational weight gain. Expand
Evidence of detrimental effects of prenatal alcohol exposure on offspring birthweight and neurodevelopment from a systematic review of quasi-experimental studies
TLDR
Based on evidence from several studies, a likely causal detrimental role of prenatal alcohol exposure on cognitive outcomes, and weaker evidence for a role in low birthweight is found. Expand
Systematic literature review on which maternal alcohol behaviours are related to fetal alcohol spectrum disorders (FASD)
TLDR
Recommendations are formulated that future studies can optimise the value of the collected dataset through specifying measurements and reporting of maternal drinking behaviours and avoiding categorised measures whenever possible. Expand
Fetal growth and maternal alcohol consumption during early pregnancy.
TLDR
Women who consume alcohol should be advised of the fetal and maternal risks of heavy consumption and of the need to quit smoking and avoid illicit drugs, and may be reassured that their alcohol consumption did not impact adversely on their baby's growth. Expand
Alcohol intake in early pregnancy and spontaneous preterm birth: a cohort study.
TLDR
No evidence that maternal alcohol intake in early pregnancy was associated with a higher risk of spontaneous preterm birth, neither for alcohol binge drinking nor for a low average weekly intake of alcohol is found. Expand
Light drinking during pregnancy: Social advantages explain positive correlates with child and early adolescent adjustment.
TLDR
Results of a series of multivariable regression models found no association between light drinking and cognitive and psychosocial outcomes up to and including the age of 14, after controlling for key confounders. Expand
Alcohol consumption during pregnancy and risk of small-for-gestational-age newborn.
TLDR
A very moderate alcohol intake during pregnancy may have a negative association with the risk of having a small for gestational age newborn. Expand
Effectiveness of psychological interventions to reduce alcohol consumption among pregnant and postpartum women: a systematic review
TLDR
Paucity of evidence, inconsistency of outcomes, large heterogeneity in the interventions and methodological weaknesses limit the ability to make final conclusions about the overall effectiveness of these interventions. Expand
Association of Prenatal Alcohol Exposure and Offspring Depression: A Negative Control Analysis of Maternal and Partner Consumption
TLDR
Maternal drinking in pregnancy was associated with increased risk of offspring depression at age 18, and the negative control comparison of paternal drinking provides some evidence that it may be causal, and this warrants further investigation. Expand
Pregnant Women’s Risk Perception of the Teratogenic Effects of Alcohol Consumption in Pregnancy
TLDR
Healthcare institutions should articulate programs that facilitate health advice regarding alcohol consumption during pregnancy, particularly when providing care for women with low educational levels, according to a structural equation model. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 60 REFERENCES
Maternal alcohol intake prior to and during pregnancy and risk of adverse birth outcomes: evidence from a British cohort
TLDR
It is found the first trimester to be the period most sensitive to the effect of alcohol on the developing fetus, and women should be advised to abstain from alcohol when planning to conceive and throughout pregnancy. Expand
EUROMAC. A European concerted action: maternal alcohol consumption and its relation to the outcome of pregnancy and child development at 18 months. Results--strategy of analysis and analysis of pregnancy outcome.
TLDR
Analyses were made of the relation between maternal alcohol consumption before and in early pregnancy and five infant outcome variables: birthweight, crown-heel length, occipitofrontal circumference and the Apgar scores at 1 and 5 minutes, finding that a poorer outcome was related to consumption of 120 g/week absolute alcohol or more. Expand
Moderate alcohol intake during pregnancy and risk of fetal death.
TLDR
Even low amounts of alcohol consumption during early pregnancy increased the risk of spontaneous abortion substantially and the results indicate that the fetus is particularly susceptible to alcohol exposure early in pregnancy. Expand
Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The generation R study.
TLDR
Average consumption of one or more but not less than one alcoholic drink per day in early or late pregnancy seems to be associated with adverse birth outcomes in the offspring. Expand
Association Between Maternal Alcohol Consumption in Early Pregnancy and Pregnancy Outcomes
TLDR
Alcohol consumption in early pregnancy was prevalent in this nulliparous cohort and there was no association between alcohol consumption before 15 weeks of gestation and small for gestational age, reduced birth weight, preeclampsia, or spontaneous preterm birth. Expand
Prenatal Alcohol Exposure and Gender Differences in Childhood Mental Health Problems: A Longitudinal Population-Based Study
TLDR
Very low levels of alcohol consumption during early pregnancy may have a negative and persistent effect on mental health outcomes, and the lack of a clear dose-response relationship and unexpected gender effects should be considered preliminary and need additional investigation. Expand
Prenatal exposure to alcohol, and gender differences on child mental health at age seven years
TLDR
Exposure to binge drinking is weakly associated with impaired behavioural and emotional development measured at age seven, and large differences in background characteristics were observed between the groups defined by cumulated alcohol exposure. Expand
Effect of Prenatal Alcohol Exposure on Childhood Academic Outcomes: Contrasting Maternal and Paternal Associations in the ALSPAC Study
TLDR
This study tested the hypothesis that low-to-moderate maternal alcohol use in pregnancy is associated with lower school test scores at age 11 in the offspring via intrauterine mechanisms, and contrasted the association of mother's alcohol consumption during pregnancy with child's National Curriculum Key Stage 2 (KS2) test scores. Expand
Preterm delivery: effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine
TLDR
Adverse social circumstances are associated with preterm birth but smoking is not, apart from an association with very early births, which runs counter to findings for fetal growth in this study, where a strong effect of smoking on fetal growth was observed but there was no evidence for any association with psychosocial factors. Expand
Impact of prenatal alcohol consumption on placenta-associated syndromes.
TLDR
The relationship between prenatal alcohol use and the risk of placenta-associated syndromes among singleton births in the Missouri maternally linked data files covering the period 1989-2005 was examined. Expand
...
1
2
3
4
5
...