Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).


the colorectal patients and the AML patients. The insertion, which started at codon 817 in exon 14, results in a frame shift mutation of MLL3, leading to a premature stop codon “TAA” at codon 827. MLL3, which belongs to the human TRX/MLL family, is an important mammalian H3K4 methyltransferase. Down-regulation of MLL3 promoted cell proliferation in HCC cell… (More)
DOI: 10.1182/blood-2012-12-467415


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