Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.

@article{Hutzler2015LowTurnoverDM,
  title={Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.},
  author={James Matthew Hutzler and Barbara J. Ring and Shelby R Anderson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2015},
  volume={43 12},
  pages={1917-28}
}
In vitro assays using liver subcellular fractions or suspended hepatocytes for characterizing the metabolism of drug candidates play an integral role in the optimization strategy employed by medicinal chemists. However, conventional in vitro assays have limitations in their ability to predict clearance and generate metabolites for low-turnover (slowly… CONTINUE READING