Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men

@article{Schellekens1990LowTR,
  title={Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men},
  author={Peter Th. A. Schellekens and Marijke Th. L. Roos and Frank De Wolf and Joep M. A. Lange and Frank A Miedema},
  journal={Journal of Clinical Immunology},
  year={1990},
  volume={10},
  pages={121-127}
}
In a cohort of 300 HIV-1-infected homosexual men, studied longitudinally, the prognostic value of T-cell proliferative responses for development of AIDS was analyzed. In 15 persons we observed that, at seroconversion, T-cell reactivity to anti-CD3 monoclonal antibody (Mab) and phytohemagglutinin (PHA) was decreased to 20 and 60% of the normal values… CONTINUE READING