Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women

@article{Pedersen2008LowSE,
  title={Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women},
  author={Steen B\onl\okke Pedersen and Jens \Olholm and S\oren Kildeberg Paulsen and Marianne Faurholt Bennetzen and Bj\orn Richelsen},
  journal={International Journal of Obesity},
  year={2008},
  volume={32},
  pages={1250-1255}
}
Objective:Calorie restriction increases the life span in a number of different organisms. This effect is dependent upon activation of the Sirt1 enzyme, and many of the beneficial effects of calorie restriction can be mimicked using resveratrol, which activates the Sirt1 enzyme. Nothing is known about this system in human adipose tissue; therefore, we investigated this system in human adipose tissue.Design:Sirt1 mRNA was measured in adipose tissue biopsies from human volunteers before and after… CONTINUE READING
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