Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin.

Abstract

ATP release from erythrocytes in response to reduced oxygen (O2) tension stimulates local vasodilation, enabling these cells to direct perfusion to areas in skeletal muscle in need of O2. Erythrocytes of humans with type 2 diabetes do not release ATP in response to low O2. Both C-peptide and insulin individually inhibit low O2-induced ATP release from… (More)
DOI: 10.1152/ajpregu.00206.2014

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@article{Richards2014LowOA, title={Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin.}, author={Jennifer P. Richards and Gina L. C. Yosten and Grant R. Kolar and Cory W Jones and Alan Stephenson and Mary L. Ellsworth and Randy S Sprague}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2014}, volume={307 7}, pages={R862-8} }