Low Molecular Weight Heparin (LMWH) Improves Peritoneal Function and Inhibits Peritoneal Fibrosis Possibly through Suppression of HIF-1α, VEGF and TGF-β1

@inproceedings{Li2015LowMW,
  title={Low Molecular Weight Heparin (LMWH) Improves Peritoneal Function and Inhibits Peritoneal Fibrosis Possibly through Suppression of HIF-1α, VEGF and TGF-β1},
  author={Juan Li and Zhi Yong Guo and Xian Hua Gao and Qi Bian and Meng Xue Jia and Xue Li Lai and Tie Wang and Xiao Bian and Hai Yan Wang},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Peritoneal fibrosis is the major cause of ultrafiltration failure, and intraperitoneal administration of Low Molecular Weight Heparin (LMWH) was reported to protect peritoneal function. But the exact mechanism of its influence on peritoneal structure and function is still unknown. METHODS A fibrosis model of rat was established by intraperitoneal (IP) administration of PD fluid and Erythromycin Lactobionate. Fifty-two rats were randomly divided into 6 groups: (1) normal control… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 27 references

H.Chen NImpact of rapamycin on peritoneal fibrosis and transport function

T Xu, JY Xie, WangWM, Ren
Blood Purif • 2012
View 5 Excerpts
Highly Influenced

Long-term intervention with heparins in a rat model of peritoneal dialysis.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis • 2009
View 6 Excerpts
Highly Influenced

Intraperitoneal heparin reduces peritoneal permeability and increases ultrafiltration in peritoneal dialysis patients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2004
View 4 Excerpts
Highly Influenced

Pleiotropic effects of heparin and heparinoids in peritoneal dialysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis • 2009
View 4 Excerpts
Highly Influenced

Chen NImpact of rapamycin on peritoneal fibrosis and transport function

T Xu, JY Xie, WangWM, H Ren
Blood Purif • 2012

Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…