Low Mitochondrial DNA Copy Number is Associated With Adverse Clinical Outcomes in Peritoneal Dialysis Patients

  title={Low Mitochondrial DNA Copy Number is Associated With Adverse Clinical Outcomes in Peritoneal Dialysis Patients},
  author={Chang-Yun Yoon and Jung Tak Park and Youn Kyung Kee and Seung Gyu Han and In Mee Han and Young Eun Kwon and Kyoung Sook Park and Mi Jung Lee and Seung Hyeok Han and Shin-Wook Kang and Tae‐Hyun Yoo},
AbstractMitochondrial dysfunction may play an important role in abnormal glucose metabolism and systemic inflammation. We aimed to investigate the relationship between mitochondrial DNA (mtDNA) copy number and clinical outcomes in peritoneal dialysis (PD) patients.We recruited 120 prevalent PD patients and determined mtDNA copy number by PCR. Primary outcome was all-cause mortality, whereas secondary outcomes included cardiovascular events, technical PD failure, and incident malignancy. Cox… 

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