Low-Level Prenatal and Postnatal Blood Lead Exposure and Adrenocortical Responses to Acute Stress in Children

@inproceedings{Gump2008LowLevelPA,
  title={Low-Level Prenatal and Postnatal Blood Lead Exposure and Adrenocortical Responses to Acute Stress in Children},
  author={Brooks B. Gump and Paul W. Stewart and Jacki Reihman and Ed Lonky and Tom Darvill and Patrick J. Parsons and Douglas A. Granger},
  booktitle={Environmental health perspectives},
  year={2008}
}
BACKGROUND A few recent studies have demonstrated heightened hypothalamic-pituitary-adrenal (HPA) axis reactivity to acute stress in animals exposed to heavy metal contaminants, particularly lead. However, Pb-induced dysregulation of the HPA axis has not yet been studied in humans. OBJECTIVE In this study, we examined children's cortisol response to acute stress (the glucocorticoid product of HPA activation) in relation to low-level prenatal and postnatal Pb exposure. METHODS Children's… CONTINUE READING